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Literature summary extracted from

  • Waizenegger, I.C.; Gimenez-Abian, J.F.; Wernic, D.; Peters, J.M.
    Regulation of human separase by securin binding and autocleavage (2002), Curr. Biol., 12, 1368-1378.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.49 C2029A no autoproteolytic cleavage, unable to cleave SCC1 Homo sapiens
3.4.22.49 S1126A cleaved autoproteolytically to the same degree as wild-type, shows similar SCC1 cleavage activity as wild-type Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.49 peptide acyloxymethyl ketone derivative of human SCC1 cleavage site peptide, chloromethyl ketone derivatives of the yeast Scc1 cleavage site Homo sapiens
3.4.22.49 securin securin inhibits separase by blocking the access of substrates to the active site Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.49 cohesin + H2O Homo sapiens separase is required for sister chromatid separation during mitosis cleaved cohesin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.49 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.49 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.49 cohesin + H2O separase is required for sister chromatid separation during mitosis Homo sapiens cleaved cohesin
-
 ?